The recent advancement of information technology has enabled artificial intelligence to rival and, in some cases, surpass human intelligence. Our daily life becomes increasingly empowered while threatened at the same time by artificial intelligence and machine learning; new economic and social paradigm also began to emerge. As we approach this critical junction, CIST 2018 calls for innovative ideas on the transformational power of information technology, artificial intelligence and machine learning on individual behavior, business strategies, economic relationships, and social changes. We also call for innovative ideas on new interplay between machine and human as well as new ways to address challenges and threats brought by the new machine age.